Draw
2025Quarter-finals
| 1 | Deportes Iquique | Bye | |
| 2 | Bye | Santa Fe | |
| 3 | Nacional Asuncion | Alianza Lima | 1 : 3, 1 : 1 |
| 4 | Bye | Boca Juniors | |
| 5 | The Strongest | Bye | |
| 6 | Bye | Bahia | |
| 7 | Boston River | Bye | |
| 8 | Bye | Nublense | |
| 9 | Monagas | Defensor Sp. | 2 : 0, 2 : 0 |
| 10 | Bye | Cerro Porteno | |
| 11 | Deportes Tolima | Bye | |
| 12 | Bye | FBC Melgar | |
| 13 | Blooming | EL Nacional | 1 : 3, 3 : 2 |
| 14 | Bye | Barcelona SC | |
| 15 | Universidad Central | Bye | |
| 16 | Bye | Corinthians |
Semi-finals
| 1 | Deportes Iquique | Santa Fe | 2 : 2, 2 : 1 |
| 2 | Alianza Lima | Boca Juniors | 2 : 2, 1 : 0 |
| 3 | The Strongest | Bahia | 0 : 3, 1 : 1 |
| 4 | Boston River | Nublense | 1 : 1, 1 : 0 |
| 5 | Monagas | Cerro Porteno | 1 : 3, 0 : 4 |
| 6 | Deportes Tolima | FBC Melgar | 0 : 1, 0 : 1 |
| 7 | EL Nacional | Barcelona SC | 1 : 1, 0 : 1 |
| 8 | Universidad Central | Corinthians | 2 : 3, 1 : 1 |
Final
| 1 | Deportes Iquique | Alianza Lima | 1 : 1, 1 : 2 |
| 2 | Bahia | Boston River | 1 : 0, 0 : 0 |
| 3 | Cerro Porteno | FBC Melgar | 4 : 2, 1 : 0 |
| 4 | Barcelona SC | Corinthians | 0 : 2, 3 : 0 |
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