The Facts
- First leg result: 6-1. Second leg.
- Real España is in very good shape now (in the last 5 games, wins – 3).
- Real España may have a physical advantage due to more rest days in recent times.
- In this match, Los Angeles is the undeniable favorite.
- In the last 1 head-to-head match, Los Angeles won 1 match, drew 0 matches, lost 0 matches, and goals 6:1.
Draw
20261/16-finals
| 1 | Toluca | Bye | |
| 2 | UNAM Pumas | San Diego FC | 1 : 0, 1 : 4 |
| 3 | Mount Pleasant | Bye | |
| 4 | Los Angeles Galaxy | Miguelito | 0 : 0, 1 : 1 |
| 5 | Cruz Azul | Vancouver FC | 5 : 0, 3 : 0 |
| 6 | Monterrey | Xelaju | 2 : 0, 1 : 1 |
| 7 | Alajuelense | Bye | |
| 8 | Los Angeles FC | Real Espana | 1 : 0, 6 : 1 |
| 9 | Inter Miami | Bye | |
| 10 | Nashville SC | Atl. Ottawa | 5 : 0, 2 : 0 |
| 11 | Club America | Olimpia | 0 : 0, 2 : 1 |
| 12 | Philadelphia Union | Defence Force | 7 : 0, 5 : 0 |
| 13 | Tigres UANL | Forge | 4 : 1, 0 : 0 |
| 14 | FC Cincinnati | Universidad O&M | 9 : 0, 4 : 0 |
| 15 | Seattle Sounders | Bye | |
| 16 | Vancouver Whitecaps | Cartagines | 2 : 0, 0 : 0 |
1/8-finals
| 1 | Toluca | San Diego FC | 4 : 0, 2 : 3 |
| 2 | Mount Pleasant | Los Angeles Galaxy | 0 : 3, 0 : 3 |
| 3 | Cruz Azul | Monterrey | 1 : 1, 3 : 2 |
| 4 | Alajuelense | Los Angeles FC | 1 : 2, 1 : 1 |
| 5 | Inter Miami | Nashville SC | 1 : 1, 0 : 0 |
| 6 | Club America | Philadelphia Union | 1 : 1, 1 : 0 |
| 7 | Tigres UANL | FC Cincinnati | 5 : 1, 0 : 3 |
| 8 | Seattle Sounders | Vancouver Whitecaps | 2 : 1, 3 : 0 |
Quarter-finals
| 1 | Toluca | Los Angeles Galaxy | 3 : 0, 4 : 2 |
| 2 | Cruz Azul | Los Angeles FC | 1 : 1, 0 : 3 |
| 3 | Nashville SC | Club America | 1 : 0, 0 : 0 |
| 4 | Tigres UANL | Seattle Sounders | 1 : 3, 2 : 0 |
Semi-finals
| 1 | Toluca | Los Angeles FC | 4 : 0, 1 : 2 |
| 2 | Nashville SC | Tigres UANL | 0 : 1, 0 : 1 |
Final
| 1 | Toluca | Tigres UANL | 2 : 1 |
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