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North Conference
South Conference
Promotion ~ LMB (Play Offs: 1/8~finals)
1/8-finals
Quarter-finals
Semi-finals
Final
2021 Main
North Conference
| Pl | W | L | PCT | |||
| 1 | Guadalajara | 63 | 46 | 17 | 500:313 | 0.730 |
| 2 | Toros de Tijuana | 65 | 40 | 25 | 351:267 | 0.615 |
| 3 | Saltillo | 66 | 36 | 30 | 438:374 | 0.545 |
| 4 | Monclova | 66 | 35 | 31 | 358:373 | 0.530 |
| 5 | Aguascalientes | 61 | 30 | 31 | 322:377 | 0.492 |
| 6 | Laguna | 64 | 31 | 33 | 338:375 | 0.484 |
| 7 | Monterrey | 63 | 30 | 33 | 361:354 | 0.476 |
| 8 | Dos Laredos | 66 | 30 | 36 | 350:335 | 0.455 |
| 9 | Durango | 65 | 20 | 45 | 327:476 | 0.308 |
South Conference
| Pl | W | L | PCT | |||
| 1 | Mexico | 64 | 41 | 23 | 374:325 | 0.641 |
| 2 | Tabasco | 66 | 36 | 30 | 309:282 | 0.545 |
| 3 | Yucatan | 64 | 34 | 30 | 332:250 | 0.531 |
| 4 | Veracruz | 66 | 35 | 31 | 369:346 | 0.530 |
| 5 | Puebla | 62 | 31 | 31 | 376:405 | 0.500 |
| 6 | Quintana Roo | 65 | 32 | 33 | 276:343 | 0.492 |
| 7 | Bravos de Leon | 66 | 29 | 37 | 384:413 | 0.439 |
| 8 | Campeche | 63 | 24 | 39 | 250:322 | 0.381 |
| 9 | Oaxaca | 65 | 20 | 45 | 329:414 | 0.308 |
Promotion ~ LMB (Play Offs: 1/8~finals)
2021 Play Offs
1/8-finals
| 1 | Guadalajara (1) | Laguna (6) | 4 : 3 |
| 3 | Toros de Tijuana (2) | Aguascalientes (5) | 4 : 3 |
| 4 | Saltillo (3) | Monclova (4) | 1 : 4 |
| 5 | Mexico (1) | Quintana Roo (6) | 4 : 1 |
| 7 | Tabasco (2) | Puebla (5) | 4 : 1 |
| 8 | Yucatan (3) | Veracruz (4) | 4 : 2 |
Quarter-finals
| 1 | Guadalajara (1) | Aguascalientes (5) | 4 : 2 |
| 2 | Toros de Tijuana (2) | Monclova (4) | 4 : 1 |
| 3 | Mexico (1) | Veracruz (4) | 4 : 1 |
| 4 | Tabasco (2) | Yucatan (3) | 1 : 4 |
Semi-finals
| 1 | Guadalajara (1) | Toros de Tijuana (2) | 2 : 4 |
| 2 | Mexico (1) | Yucatan (3) | 1 : 4 |
Final
| 1 | Toros de Tijuana (2) | Yucatan (3) | 4 : 3 |
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