Draw
Play Offs1/64-finals
| 1 | Duke | Bye | |
| 2 | Bye | Siena | |
| 3 | Ohio State | Bye | |
| 4 | Bye | TCU | |
| 5 | St. John's (N.Y.) | Bye | |
| 6 | Bye | Northern Iowa | |
| 7 | Kansas | Bye | |
| 8 | Bye | California Baptist | |
| 9 | Louisville | Bye | |
| 10 | Bye | South Florida | |
| 11 | Michigan State | Bye | |
| 12 | Bye | North Dakota St | |
| 13 | UCLA | Bye | |
| 14 | Bye | UCF Knights | |
| 15 | UConn | Bye | |
| 16 | Bye | Furman | |
| 17 | Florida | Bye | |
| 18 | Lehigh | Prairie View A&M | 55 : 67 |
| 19 | Clemson | Bye | |
| 20 | Bye | Iowa | |
| 21 | Vanderbilt | Bye | |
| 22 | Bye | McNeese State | |
| 23 | Nebraska | Bye | |
| 24 | Bye | Troy | |
| 25 | North Carolina | Bye | |
| 26 | Bye | VCU Rams | |
| 27 | Illinois | Bye | |
| 28 | Bye | Penn | |
| 29 | St. Marys (CA) | Bye | |
| 30 | Bye | Texas A&M | |
| 31 | Houston | Bye | |
| 32 | Bye | Idaho | |
| 33 | Arizona | Bye | |
| 34 | Bye | LIU Sharks | |
| 35 | Villanova | Bye | |
| 36 | Bye | Utah State | |
| 37 | Wisconsin | Bye | |
| 38 | Bye | High Point | |
| 39 | Arkansas | Bye | |
| 40 | Bye | Hawaii | |
| 41 | Brigham Young | Bye | |
| 42 | NC State | Texas | 66 : 68 |
| 43 | Gonzaga | Bye | |
| 44 | Bye | Kennesaw State | |
| 45 | Miami (FL) | Bye | |
| 46 | Bye | Missouri | |
| 47 | Purdue | Bye | |
| 48 | Bye | Queens Royals | |
| 49 | Michigan | Bye | |
| 50 | Howard | UMBC Retrievers | 86 : 83 |
| 51 | Georgia | Bye | |
| 52 | Bye | St. Louis Billikens | |
| 53 | Texas Tech | Bye | |
| 54 | Bye | Akron | |
| 55 | Alabama | Bye | |
| 56 | Bye | Hofstra | |
| 57 | Tennessee | Bye | |
| 58 | SMU Mustangs | Miami (Ohio) | 79 : 89 |
| 59 | Virginia | Bye | |
| 60 | Bye | Wright State | |
| 61 | Kentucky | Bye | |
| 62 | Bye | Santa Clara | |
| 63 | Iowa State | Bye | |
| 64 | Bye | Tennessee State |
1/32-finals
| 1 | Duke | Siena | 71 : 65 |
| 2 | Ohio State | TCU | 64 : 66 |
| 3 | St. John's (N.Y.) | Northern Iowa | 79 : 53 |
| 4 | Kansas | California Baptist | 68 : 60 |
| 5 | Louisville | South Florida | 83 : 79 |
| 6 | Michigan State | North Dakota St | 92 : 67 |
| 7 | UCLA | UCF Knights | 75 : 71 |
| 8 | UConn | Furman | 82 : 71 |
| 9 | Florida | Prairie View A&M | 114 : 55 |
| 10 | Clemson | Iowa | 61 : 67 |
| 11 | Vanderbilt | McNeese State | 78 : 68 |
| 12 | Nebraska | Troy | 76 : 47 |
| 13 | North Carolina | VCU Rams | 78 : 82 |
| 14 | Illinois | Penn | 105 : 70 |
| 15 | St. Marys (CA) | Texas A&M | 50 : 63 |
| 16 | Houston | Idaho | 78 : 47 |
| 17 | Arizona | LIU Sharks | 92 : 58 |
| 18 | Villanova | Utah State | 76 : 86 |
| 19 | Wisconsin | High Point | 82 : 83 |
| 20 | Arkansas | Hawaii | 97 : 78 |
| 21 | Brigham Young | Texas | 71 : 79 |
| 22 | Gonzaga | Kennesaw State | 73 : 64 |
| 23 | Miami (FL) | Missouri | 80 : 66 |
| 24 | Purdue | Queens Royals | 104 : 71 |
| 25 | Michigan | Howard | 101 : 80 |
| 26 | Georgia | St. Louis Billikens | 77 : 102 |
| 27 | Texas Tech | Akron | 91 : 71 |
| 28 | Alabama | Hofstra | 90 : 70 |
| 29 | Tennessee | Miami (Ohio) | 78 : 56 |
| 30 | Virginia | Wright State | 82 : 73 |
| 31 | Kentucky | Santa Clara | 89 : 84 |
| 32 | Iowa State | Tennessee State | 108 : 74 |
1/16-finals
| 1 | Duke | TCU | 81 : 58 |
| 2 | St. John's (N.Y.) | Kansas | 67 : 65 |
| 3 | Louisville | Michigan State | 69 : 77 |
| 4 | UCLA | UConn | 57 : 73 |
| 5 | Florida | Iowa | 72 : 73 |
| 6 | Vanderbilt | Nebraska | 72 : 74 |
| 7 | VCU Rams | Illinois | 55 : 76 |
| 8 | Texas A&M | Houston | 57 : 88 |
| 9 | Arizona | Utah State | 78 : 66 |
| 10 | High Point | Arkansas | 88 : 94 |
| 11 | Texas | Gonzaga | 74 : 68 |
| 12 | Miami (FL) | Purdue | 69 : 79 |
| 13 | Michigan | St. Louis Billikens | 95 : 72 |
| 14 | Texas Tech | Alabama | 65 : 90 |
| 15 | Tennessee | Virginia | 79 : 72 |
| 16 | Kentucky | Iowa State | 63 : 82 |
1/8-finals
| 1 | Duke | St. John's (N.Y.) | 80 : 75 |
| 2 | Michigan State | UConn | 63 : 67 |
| 3 | Iowa | Nebraska | 77 : 71 |
| 4 | Illinois | Houston | 65 : 55 |
| 5 | Arizona | Arkansas | 109 : 88 |
| 6 | Texas | Purdue | 77 : 79 |
| 7 | Michigan | Alabama | 90 : 77 |
| 8 | Tennessee | Iowa State | 76 : 62 |
Quarter-finals
| 1 | Duke | UConn | 72 : 73 |
| 2 | Iowa | Illinois | 59 : 71 |
| 3 | Arizona | Purdue | 79 : 64 |
| 4 | Michigan | Tennessee | 95 : 62 |
Semi-finals
| 1 | UConn | Illinois | 71 : 62 |
| 2 | Arizona | Michigan | 73 : 91 |
Final
| 1 | UConn | Michigan | 63 : 69 |
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