2021 Main
| Pl | W | L | PCT | |||
| 1 | Catalans Dragons | 23 | 19 | 4 | 688:398 | 0.826 |
| 2 | St Helens | 21 | 16 | 5 | 548:229 | 0.762 |
| 3 | Warrington | 21 | 15 | 5 | 588:354 | 0.738 |
| 4 | Wigan | 25 | 15 | 10 | 387:385 | 0.600 |
| 5 | Leeds | 24 | 13 | 11 | 556:440 | 0.542 |
| 6 | Hull KR | 20 | 10 | 10 | 497:458 | 0.500 |
| 7 | Castleford | 23 | 11 | 12 | 437:552 | 0.478 |
| 8 | Hull FC | 21 | 8 | 12 | 409:476 | 0.405 |
| 9 | Huddersfield | 24 | 9 | 15 | 460:516 | 0.375 |
| 10 | Wakefield | 24 | 9 | 15 | 482:548 | 0.375 |
| 11 | Salford | 22 | 7 | 15 | 402:584 | 0.318 |
| 12 | Leigh | 22 | 2 | 20 | 356:870 | 0.091 |
Promotion ~ Super League (Play Offs: Semi~finals)
Promotion ~ Super League (Play Offs: Quarter~finals)
Relegation
2021 Play Offs
Quarter-finals
| 1 | Catalans Dragons (1) | Bye | |
| 2 | Warrington (3) | Hull KR (6) | 0 : 19 |
| 3 | St Helens (2) | Bye | |
| 4 | Wigan (4) | Leeds (5) | 0 : 8 |
Semi-finals
| 1 | Catalans Dragons (1) | Hull KR (6) | 28 : 10 |
| 2 | St Helens (2) | Leeds (5) | 36 : 8 |
Final
| 1 | Catalans Dragons (1) | St Helens (2) | 10 : 12 |
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