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Group A
Group B
Group C
Ranking of fourth-placed teams
Promotion ~ Challenge Cup (Play Offs)
1/8-finals
Quarter-finals
Semi-finals
Final
2021/22 Main
Group A
| Pl | W | D | L | Pts | |||
| 1 | RC Toulonnais | 4 | 3 | 0 | 1 | 107:57 | 16 |
| 2 | Newcastle Falcons | 4 | 3 | 0 | 1 | 73:89 | 14 |
| 3 | Biarritz Olympique | 3 | 2 | 0 | 1 | 59:47 | 12 |
| 4 | Worcester Warriors | 3 | 1 | 0 | 2 | 85:91 | 9 |
| 5 | Zebre | 4 | 0 | 0 | 4 | 75:115 | 2 |
Group B
| Pl | W | D | L | Pts | |||
| 1 | Lyon | 4 | 4 | 0 | 0 | 122:57 | 18 |
| 2 | Gloucester | 4 | 3 | 0 | 1 | 161:84 | 16 |
| 3 | Benetton | 4 | 2 | 0 | 2 | 75:95 | 8 |
| 4 | USA Perpignan | 4 | 1 | 0 | 3 | 54:138 | 4 |
| 5 | Dragons | 4 | 0 | 0 | 4 | 74:112 | 2 |
Group C
| Pl | W | D | L | Pts | |||
| 1 | Edinburgh | 4 | 3 | 0 | 1 | 161:47 | 15 |
| 2 | London Irish | 3 | 2 | 0 | 1 | 78:82 | 12 |
| 3 | Saracens | 4 | 2 | 0 | 2 | 118:78 | 11 |
| 4 | CA Brive | 3 | 1 | 0 | 2 | 41:146 | 6 |
| 5 | Section Paloise | 4 | 1 | 0 | 3 | 75:120 | 5 |
Ranking of fourth-placed teams
| Pl | W | D | L | Pts | |||
| 1 | Worcester Warriors | 3 | 1 | 0 | 2 | 85:91 | 9 |
| 2 | CA Brive | 3 | 1 | 0 | 2 | 41:146 | 6 |
| 3 | USA Perpignan | 4 | 1 | 0 | 3 | 54:138 | 4 |
Promotion ~ Challenge Cup (Play Offs)
2021/22 Play Offs
1/8-finals
| 1 | Lyon | Worcester Warriors | 31 : 17 |
| 2 | Newcastle Falcons | Glasgow Warriors | 17 : 27 |
| 3 | Edinburgh | Bath | 41 : 19 |
| 4 | Biarritz Olympique | Wasps | 29 : 39 |
| 5 | RC Toulonnais | Benetton | 36 : 17 |
| 6 | London Irish | Castres Olympique | 64 : 27 |
| 7 | Gloucester | Northampton Saints | 31 : 21 |
| 8 | Saracens | Cardiff Rugby | 40 : 33 |
Quarter-finals
| 1 | Lyon | Glasgow Warriors | 35 : 27 |
| 2 | Edinburgh | Wasps | 30 : 34 |
| 3 | RC Toulonnais | London Irish | 19 : 18 |
| 4 | Gloucester | Saracens | 15 : 44 |
Semi-finals
| 1 | Lyon | Wasps | 20 : 18 |
| 2 | RC Toulonnais | Saracens | 25 : 16 |
Final
| 1 | Lyon | RC Toulonnais | 30 : 12 |
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