2021 Main
| Pl | W | D | L | Diff | Pts | |||
| 1 | Independiente Petrolero | 30 | 20 | 5 | 5 | 59:33 | 26 | 65 |
| 2 | Always Ready | 30 | 19 | 7 | 4 | 66:31 | 35 | 64 |
| 3 | The Strongest | 30 | 19 | 6 | 5 | 57:24 | 33 | 63 |
| 4 | Bolivar | 30 | 16 | 8 | 6 | 63:29 | 34 | 56 |
| 5 | Royal Pari | 30 | 16 | 3 | 11 | 66:45 | 21 | 51 |
| 6 | Oriente Petrolero | 30 | 15 | 6 | 9 | 46:29 | 17 | 51 |
| 7 | Wilstermann | 30 | 15 | 4 | 11 | 64:48 | 16 | 49 |
| 8 | Guabira | 30 | 13 | 5 | 12 | 47:47 | 0 | 44 |
| 9 | Palmaflor | 30 | 11 | 7 | 12 | 42:45 | -3 | 40 |
| 10 | Nacional Potosi | 30 | 10 | 9 | 11 | 45:46 | -1 | 39 |
| 11 | Santa Cruz | 30 | 11 | 5 | 14 | 39:47 | -8 | 38 |
| 12 | Aurora | 30 | 9 | 6 | 15 | 40:51 | -11 | 33 |
| 13 | Tomayapo | 30 | 9 | 5 | 16 | 28:45 | -17 | 32 |
| 14 | Blooming | 30 | 7 | 5 | 18 | 34:56 | -22 | 26 |
| 15 | Real Potosi | 30 | 7 | 4 | 19 | 30:63 | -33 | 25 |
| 16 | San Jose | 30 | 0 | 1 | 29 | 9:96 | -87 | -11 |
Promotion ~ Copa Libertadores (Group Stage: )
Promotion ~ Copa Libertadores (Qualification: )
Promotion ~ Copa Sudamericana (Group Stage: )
Division Profesional (Relegation)
Relegation
2021 Relegation
Final
| 1 | Real Potosi | U. Sucre | 0 : 2, 1 : 2 |
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