2021 First stage
Group A
| Pl | W | D | L | Diff | Pts | |||
| 1 | Dourados | 8 | 6 | 0 | 2 | 17:8 | 9 | 18 |
| 2 | Aquidauanense | 8 | 5 | 1 | 2 | 13:4 | 9 | 16 |
| 3 | Operario MS | 8 | 4 | 0 | 4 | 19:11 | 8 | 12 |
| 4 | Aguia Negra | 8 | 3 | 2 | 3 | 16:13 | 3 | 11 |
| 5 | Novoperario | 8 | 0 | 1 | 7 | 2:31 | -29 | 1 |
Group B
| Pl | W | D | L | Diff | Pts | |||
| 1 | Costa Rica | 8 | 6 | 2 | 0 | 14:2 | 12 | 20 |
| 2 | Comercial MS | 8 | 3 | 3 | 2 | 11:10 | 1 | 12 |
| 3 | Uniao | 8 | 3 | 2 | 3 | 12:11 | 1 | 11 |
| 4 | Chapadao | 8 | 3 | 1 | 4 | 13:14 | -1 | 10 |
| 5 | Tres Lagoas | 8 | 1 | 0 | 7 | 9:22 | -13 | 3 |
Promotion ~ Campeonato Sul~Matogrossense (Second stage: )
Relegation
2021 Second stage
| Pl | W | D | L | Diff | Pts | |||
| 1 | Costa Rica | 10 | 8 | 1 | 1 | 21:4 | 17 | 25 |
| 2 | Dourados | 10 | 6 | 2 | 2 | 14:9 | 5 | 20 |
| 3 | Operario MS | 10 | 5 | 2 | 3 | 16:14 | 2 | 17 |
| 4 | Aquidauanense | 10 | 3 | 1 | 6 | 12:12 | 0 | 10 |
| 5 | Comercial MS | 10 | 2 | 3 | 5 | 10:17 | -7 | 9 |
| 6 | Uniao | 10 | 1 | 1 | 8 | 7:24 | -17 | 4 |
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