2021 Main
| Pl | W | D | L | Diff | Pts | |||
| 1 | U. Catolica | 32 | 22 | 2 | 8 | 65:34 | 31 | 68 |
| 2 | Colo Colo | 32 | 19 | 5 | 8 | 49:26 | 23 | 62 |
| 3 | A. Italiano | 32 | 14 | 12 | 6 | 39:31 | 8 | 54 |
| 4 | Union La Calera | 32 | 15 | 6 | 11 | 41:40 | 1 | 51 |
| 5 | U. Espanola | 32 | 15 | 3 | 14 | 48:50 | -2 | 48 |
| 6 | Antofagasta | 32 | 12 | 11 | 9 | 34:36 | -2 | 47 |
| 7 | Nublense | 32 | 11 | 11 | 10 | 49:37 | 12 | 44 |
| 8 | Palestino | 32 | 11 | 8 | 13 | 48:50 | -2 | 41 |
| 9 | Cobresal | 32 | 11 | 7 | 14 | 40:39 | 1 | 40 |
| 10 | La Serena | 32 | 9 | 12 | 11 | 40:42 | -2 | 39 |
| 11 | U. De Chile | 32 | 10 | 9 | 13 | 34:37 | -3 | 39 |
| 12 | Everton | 32 | 10 | 9 | 13 | 29:35 | -6 | 39 |
| 13 | O'Higgins | 32 | 9 | 11 | 12 | 31:41 | -10 | 38 |
| 14 | Curico Unido | 32 | 8 | 13 | 11 | 37:39 | -2 | 37 |
| 15 | Huachipato | 32 | 8 | 13 | 11 | 36:41 | -5 | 37 |
| 16 | Melipilla | 32 | 10 | 8 | 14 | 39:51 | -12 | 32 |
| 17 | S. Wanderers | 32 | 5 | 6 | 21 | 24:54 | -30 | 21 |
Promotion ~ Copa Libertadores (Group Stage: )
Promotion ~ Copa Libertadores (Qualification: )
Promotion ~ Copa Sudamericana (Group Stage: )
Primera Division (Relegation)
Relegation ~ Primera B
2021 Relegation
Final
| 1 | Copiapo | Huachipato | 0 : 1, 2 : 3 |
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