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Promotion ~ Liga Pro (First stage: )
Relegation
2022
| Pl | W | D | L | Diff | Pts | |||
| 1 | EL Nacional | 36 | 18 | 9 | 9 | 54:37 | 17 | 63 |
| 2 | Ind. Juniors | 36 | 15 | 11 | 10 | 44:33 | 11 | 56 |
| 3 | Libertad | 36 | 15 | 11 | 10 | 42:38 | 4 | 56 |
| 4 | America de Quito | 36 | 13 | 15 | 8 | 41:31 | 10 | 54 |
| 5 | Imbabura | 36 | 13 | 8 | 15 | 47:51 | -4 | 47 |
| 6 | Chacaritas | 36 | 11 | 10 | 15 | 30:38 | -8 | 43 |
| 7 | Buhos ULVR | 36 | 9 | 15 | 12 | 33:38 | -5 | 42 |
| 8 | Manta | 36 | 10 | 12 | 14 | 29:39 | -10 | 42 |
| 9 | Santo Domingo | 36 | 9 | 12 | 15 | 31:36 | -5 | 39 |
| 10 | Olmedo | 36 | 10 | 11 | 15 | 33:43 | -10 | 38 |
Promotion ~ Liga Pro (First stage: )
Relegation
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