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Promotion ~ CAF Champions League (Qualification: )
Relegation
2022
| Pl | W | D | L | Diff | Pts | |||
| 1 | Big Bullets | 30 | 22 | 7 | 1 | 69:21 | 48 | 73 |
| 2 | Blue Eagles | 30 | 18 | 9 | 3 | 39:10 | 29 | 63 |
| 3 | Kamuzu Barracks | 30 | 16 | 9 | 5 | 37:19 | 18 | 57 |
| 4 | Mighty Wanderers | 30 | 16 | 8 | 6 | 53:26 | 27 | 56 |
| 5 | Silver Strikers | 30 | 14 | 9 | 7 | 38:26 | 12 | 51 |
| 6 | MAFCO | 30 | 14 | 8 | 8 | 49:26 | 23 | 50 |
| 7 | Moyale Barracks | 30 | 14 | 4 | 12 | 38:32 | 6 | 46 |
| 8 | Civo Utd | 30 | 10 | 15 | 5 | 35:25 | 10 | 45 |
| 9 | Dedza Dynamos | 30 | 11 | 8 | 11 | 29:36 | -7 | 41 |
| 10 | Ekwendeni Hammers | 30 | 8 | 10 | 12 | 33:35 | -2 | 34 |
| 11 | Karonga United | 30 | 8 | 8 | 14 | 26:42 | -16 | 32 |
| 12 | Mighty Tigers | 30 | 8 | 7 | 15 | 23:38 | -15 | 31 |
| 13 | Red Lions | 30 | 7 | 8 | 15 | 27:38 | -11 | 29 |
| 14 | Sable Farming | 30 | 6 | 6 | 18 | 24:44 | -20 | 24 |
| 15 | TN Stars | 30 | 4 | 5 | 21 | 24:68 | -44 | 17 |
| 16 | Rumphi United | 30 | 3 | 1 | 26 | 15:73 | -58 | 10 |
Promotion ~ CAF Champions League (Qualification: )
Relegation
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