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Promotion ~ AFC Champions League
Promotion ~ AFC Champions League (Qualification: )
Promotion ~ AFC Cup
Super League (Relegation)
Relegation
Final
2021 Main
| Pl | W | D | L | Diff | Pts | |||
| 1 | Pakhtakor | 26 | 19 | 3 | 4 | 51:18 | 33 | 60 |
| 2 | Sogdiana | 26 | 12 | 11 | 3 | 28:15 | 13 | 47 |
| 3 | OKMK | 26 | 13 | 8 | 5 | 34:25 | 9 | 47 |
| 4 | Nasaf Qarshi | 26 | 13 | 6 | 7 | 42:24 | 18 | 45 |
| 5 | Bunyodkor | 26 | 13 | 6 | 7 | 43:30 | 13 | 45 |
| 6 | Navbahor Namangan | 26 | 10 | 9 | 7 | 23:19 | 4 | 39 |
| 7 | Lok. Tashkent | 26 | 11 | 6 | 9 | 37:32 | 5 | 39 |
| 8 | Kokand 1912 | 26 | 9 | 9 | 8 | 37:36 | 1 | 36 |
| 9 | Qizilqum | 26 | 7 | 10 | 9 | 26:29 | -3 | 31 |
| 10 | Termez Surkhon | 26 | 7 | 4 | 15 | 17:43 | -26 | 25 |
| 11 | Metallurg Bekabad | 26 | 8 | 1 | 17 | 22:35 | -13 | 25 |
| 12 | Mashal Muborak | 26 | 5 | 8 | 13 | 21:35 | -14 | 23 |
| 13 | Andijan | 26 | 4 | 7 | 15 | 22:41 | -19 | 19 |
| 14 | Turon | 26 | 3 | 8 | 15 | 16:37 | -21 | 17 |
Promotion ~ AFC Champions League
Promotion ~ AFC Champions League (Qualification: )
Promotion ~ AFC Cup
Super League (Relegation)
Relegation
2021 Relegation
Final
| 1 | Olympic | Mashal Muborak | 3 : 1 |
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