2022 Group Stage
Group A
| Pl | W | D | L | Diff | Pts | |||
| 1 | Lanus | 6 | 3 | 2 | 1 | 7:4 | 3 | 11 |
| 2 | Barcelona SC | 6 | 2 | 3 | 1 | 9:8 | 1 | 9 |
| 3 | Wanderers | 6 | 2 | 2 | 2 | 6:7 | -1 | 8 |
| 4 | Metropolitanos | 6 | 0 | 3 | 3 | 3:6 | -3 | 3 |
Group B
| Pl | W | D | L | Diff | Pts | |||
| 1 | FBC Melgar | 6 | 4 | 0 | 2 | 10:6 | 4 | 12 |
| 2 | Racing Club | 6 | 4 | 0 | 2 | 7:5 | 2 | 12 |
| 3 | Cuiaba | 6 | 2 | 0 | 4 | 7:10 | -3 | 6 |
| 4 | River Plate | 6 | 2 | 0 | 4 | 5:8 | -3 | 6 |
Group C
| Pl | W | D | L | Diff | Pts | |||
| 1 | Santos | 6 | 3 | 2 | 1 | 7:5 | 2 | 11 |
| 2 | Union La Calera | 6 | 3 | 2 | 1 | 6:4 | 2 | 11 |
| 3 | U. Catolica | 6 | 1 | 2 | 3 | 7:8 | -1 | 5 |
| 4 | Banfield | 6 | 1 | 2 | 3 | 3:6 | -3 | 5 |
Group D
| Pl | W | D | L | Diff | Pts | |||
| 1 | Sao Paulo | 6 | 5 | 1 | 0 | 12:3 | 9 | 16 |
| 2 | Everton | 6 | 3 | 2 | 1 | 7:4 | 3 | 11 |
| 3 | Ayacucho | 6 | 1 | 1 | 4 | 5:8 | -3 | 4 |
| 4 | Wilstermann | 6 | 0 | 2 | 4 | 2:11 | -9 | 2 |
Group E
| Pl | W | D | L | Diff | Pts | |||
| 1 | Internacional | 6 | 3 | 3 | 0 | 12:5 | 7 | 12 |
| 2 | Guairena | 6 | 2 | 4 | 0 | 10:8 | 2 | 10 |
| 3 | Ind. Medellin | 6 | 1 | 2 | 3 | 8:11 | -3 | 5 |
| 4 | Nueve de Octubre | 6 | 1 | 1 | 4 | 9:15 | -6 | 4 |
Group F
| Pl | W | D | L | Diff | Pts | |||
| 1 | Atletico GO | 6 | 4 | 1 | 1 | 11:5 | 6 | 13 |
| 2 | LDU Quito | 6 | 3 | 2 | 1 | 11:9 | 2 | 11 |
| 3 | Antofagasta | 6 | 2 | 0 | 4 | 6:11 | -5 | 6 |
| 4 | Defensa y Justicia | 6 | 1 | 1 | 4 | 8:11 | -3 | 4 |
Group G
| Pl | W | D | L | Diff | Pts | |||
| 1 | Ceara | 6 | 6 | 0 | 0 | 17:1 | 16 | 18 |
| 2 | Independiente | 6 | 4 | 0 | 2 | 13:4 | 9 | 12 |
| 3 | General Caballero JLM | 6 | 1 | 1 | 4 | 2:15 | -13 | 4 |
| 4 | La Guaira | 6 | 0 | 1 | 5 | 1:13 | -12 | 1 |
Group H
| Pl | W | D | L | Diff | Pts | |||
| 1 | Union de Santa Fe | 6 | 3 | 3 | 0 | 10:2 | 8 | 12 |
| 2 | Fluminense | 6 | 3 | 2 | 1 | 15:5 | 10 | 11 |
| 3 | Junior | 6 | 3 | 1 | 2 | 10:8 | 2 | 10 |
| 4 | Oriente Petrolero | 6 | 0 | 0 | 6 | 3:23 | -20 | 0 |
Promotion ~ Copa Sudamericana (Play Offs: 1/8~finals)
2022 Play Offs
1/8-finals
| 1 | Santos (8) | Dep. Tachira (14) | 1 : 2, 1 : 1 |
| 2 | Lanus (7) | Ind. del Valle (10) | 0 : 0, 1 : 2 |
| 3 | FBC Melgar (6) | Dep. Cali (9) | 2 : 1, 0 : 0 |
| 4 | Internacional (5) | Colo Colo (13) | 4 : 1, 0 : 2 |
| 5 | Union de Santa Fe (4) | Nacional (12) | 1 : 2, 0 : 2 |
| 6 | Atletico GO (3) | Olimpia Asuncion (11) | 3 : 0, 0 : 2 |
| 7 | Ceara (1) | The Strongest (15) | 3 : 0, 2 : 1 |
| 8 | Sao Paulo (2) | U. Catolica (16) | 4 : 1, 4 : 2 |
Quarter-finals
| 1 | Dep. Tachira (14) | Ind. del Valle (10) | 1 : 4, 0 : 1 |
| 2 | FBC Melgar (6) | Internacional (5) | 1 : 0, 0 : 0 |
| 3 | Nacional (12) | Atletico GO (3) | 0 : 3, 0 : 1 |
| 4 | Ceara (1) | Sao Paulo (2) | 2 : 2, 0 : 1 |
Semi-finals
| 1 | Ind. del Valle (10) | FBC Melgar (6) | 3 : 0, 3 : 0 |
| 2 | Atletico GO (3) | Sao Paulo (2) | 0 : 3, 3 : 1 |
Final
| 1 | Ind. del Valle (10) | Sao Paulo (2) | 2 : 0 |
2022 Qualification
Final
| 1 | Wilstermann | Guabira | 0 : 3, 4 : 0 |
| 2 | Royal Pari | Oriente Petrolero | 0 : 3, 2 : 3 |
| 3 | U. Espanola | Antofagasta | 1 : 1, 1 : 2 |
| 4 | Nublense | Union La Calera | 1 : 2, 0 : 0 |
| 5 | La Equidad | Junior | 1 : 3, 0 : 0 |
| 6 | Ind. Medellin | America De Cali | 2 : 2, 2 : 1 |
| 7 | Delfin | Nueve de Octubre | 0 : 2, 1 : 1 |
| 8 | Mushuc Runa | LDU Quito | 1 : 1, 0 : 2 |
| 9 | Nacional Asuncion | Guairena | 0 : 0, 0 : 1 |
| 10 | Sol de America | General Caballero JLM | 1 : 2, 0 : 3 |
| 11 | Ayacucho | Sport Boys | 2 : 3, 2 : 0 |
| 12 | Cienciano | FBC Melgar | 0 : 1, 1 : 1 |
| 13 | Wanderers | Cerro Largo | 1 : 0, 2 : 1 |
| 14 | Liverpool M. | River Plate | 0 : 2, 0 : 1 |
| 15 | Estudiantes Merida | Metropolitanos | 0 : 4, 0 : 2 |
| 16 | Hermanos Colmenarez | La Guaira | 0 : 3, 2 : 0 |
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